PUBLICATIONS
Click Here: Complete Publication List (Google Scholar)
Noakes, TD., Prins PJ., Volek JS., D’Agostino DP., Koutnik AP.* The effect of low-carbohydrate high-fat diets on the crossover point during exercise of increasing intensity. Frontiers in Physiology. 2023
Prins PJ., Noakes, TD., Buga A., D’Agostino DP., Volek JS., Buxton JD., Heckman K., Jones DW., Tobias NE., Grose HM., Jenkins AK., Jancay KT., Koutnik AP.* Low and High Carbohydrate Isocaloric Diets on Performance, Fat Oxidation, Glucose and Cardiometabolic Health in Middle Age Athletes. Frontiers in Nutrition. 2023
Buga A., Crabtree CD., Decker D., Stoner J., Robinson B., Kackley ML., Bedell TN., Buxton, JD., McClure T., D’Agostino DP., Beradi A., Cline S., Fleck T., Krout J., Newby D., Koutnik AP., Volek JS., Prins PJ. Metabolic and Ruck Performance Effects of a Novel, Light-Weight, Energy-Dense Ketogenic Bar. Experimental Physiology. 2023
Rogers C.Q., Ramirez M., Landon C.S., DeBlasi J.M., Koutnik A.P., Ari C., D’Agostino D.P. A Glutamine Scavenging Protocol Combined with Deanna Protocol in SOD1-G93A Mouse Model of ALS. Nutrients. 2023
Miyatsu T., Smith BM., Koutnik AP., Pirolli P., Broderick TJ. Resting-State Heart Rate Variability After Stressful Events as a Measure of Stress Tolerance Among Elite Performers. Frontiers in Physiology. 2023
Evans M., McClure T., Koutnik, AP., Egan, B. Exogenous Ketones Supplements in Athletic Contexts: Past, Present, and Future. Sports Medicine. 2022
Prins PJ., Buxton, JD., McClure, TS., D’Agostino, DP., Ault, DL., Welton, GL., Jones, DW., Atwell, AD., Slack, MA., Slack, ML., Williams, CE., Blanchflower, ME., Kannel, KK., Faulkner, MN., Szmaziasz, HL., Croll, SM., Stanforth, LM., Harris, TD., Gwaltney, HC., & Koutnik AP*. Ketone Bodies Impact on Hypoxic CO2 Retention Protocol During Exercise. Frontiers in Physiology. 2021.
Koutnik AP*, Favre ME, Noboa K, Sanchez-Gonzalez MA, Moss SE, Goubran B, Ari C, Poff AM, Rogers CQ, DeBlasi JM, Samy B, Moussa M, Serrador JM, D’Agostino PD. Human adaptations to multiday saturation on NASA NEEMO. Front Physiol. 2021;11:610000.
Lennerz BS, Koutnik AP, Azova S, Wolfsdorf JI, Ludwig DS. Carbohydrate restriction for diabetes: rediscovering centuries-old wisdom. J Clin Invest. 2021;131(1):e142246.
Koutnik AP*, Poff AM, Ward NP, DeBlasi JM, Soliven MA, Romero MA, Roberson PA, Fox CD, Robers MD, D’Agostino DP. Ketone bodies attenuate wasting in models of atrophy. J Cachexia Sarcopenia Muscle. 2020;11(4):973-996.
Stubbs, BJ, Koutnik AP, Volek JS, Newman JC. From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience. GeroScience. 2020.
Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC. Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. Med (N Y). 2020;1(1):43-65.
Poff AM, Koutnik AP, Egan B. Nutritional Ketosis with Ketogenic Diets or Exogenous Ketones: Features, Convergence, and Divergence. Curr Sports Med Rep. 2020;19(7):251-259.
Deemer SE, Davis RAH, Roberts BM, Smith DL, Koutnik AP, Poff AM, D’Agostino DP, Plaisance EP. Exogenous dietary ketone ester decreases body weight and adiposity in mice housed at thermoneutrality. Obesity. 2020;28(8):1447-1455.
Ari C, Murdun C, Goldhagen C, Koutnik AP, Bharwani SR, Diamond DM, Kindy M, D'Agostino DP, Kovacs Z. Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models. Nutrients. 2020;12(8):2459.
Prins PJ, Koutnik AP, D'Agostino DP, Rogers CQ, Seibert JF, Breckenridge JA, Jackson DS, Ryan EJ, Buxton JD, Ault DL. Effects of an Exogenous Ketone Supplement on Five-Kilometer Running Performance. J Hum Kinet. 2020;72:115-127.
Ari C, Murdun C, Koutnik AP, Goldhagen CR, Rogers C, Park C, Bharwani S, Diamond DM, Kindy MS, D’Agostino DP, Kovasc Z. Exogenous ketones lower blood glucose level in rested and exercised rodent models. Nutrients. 2019;11(10):2230.
Deemer SE, Davis RAH, Gower BA, Koutnik AP, Poff AM, Dickinson SL, Allison DB, D’Agostino DP, Plaisance EP. Concentration-dependent effects of a dietary ketone ester on components of energy balance in mice. Front Nutr. 2019;6:56.
Koutnik AP, D'Agostino DP, Egan B. Anticatabolic Effects of Ketone Bodies in Skeletal Muscle. Trends Endocrinol Metab. 2019; pii: S1043-2760(19)30012-8.
Ari C, Koutnik AP, DeBlasi J, Landon C, Rogers CQ, Vallas J, Bharwani S, Puchowicz M, Bederman I, Diamond DM, Kindy MS, Dead JB, D'Agostino DP. Delaying latency to hyperbaric oxygen-induce CNS oxygen toxicity seizures by combinations of exogenous ketone supplements. Physiol Rep. 2019;7(1):e13961.
Ari C, Kovács Z, Murdun C, Koutnik AP, Goldhagen CR, Rogers C, Diamond D, D'Agostino DP. Nutritional ketosis delays the onset of isoflurane induced anesthesia. BMC Anesthesiology. 2018;18:85.
Koutnik AP*. Stair climbing exercise as a novel health intervention for menopause: cardiovascular and skeletal muscle implications. Menopause. 2018;25(7):721-722.
Stubbs BJ, Koutnik AP, Poff AM, Ford KM, D’Agostino DP. Commentary: Ketone Diester Ingestion Impairs Time-Trial Performance in Professional Cyclists. Frontiers in Physiology. 2018;9:279.
Poff A, Koutnik AP, Egan KM, Sahebjam S, D'Agostino D, Kumar NB. Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma. Semin Cancer Biol. 2017; S1044-579X.
Ward NP, Poff AM, Koutnik AP, D'Agostino D. Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells. PLoS One. 2017;12(6):e0180061.
Dossat AM, Sanchez-Gonzalez MA, Koutnik AP, et al. Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy. The FASEB Journal. 2017;31(6):2492-2506.
Ari C, Kovács Z, Juhasz G, Murdun C, Goldhagen CR, Koutnik AP, Poff AM, Kesl SL, D'Agostino DP. Corrigendum: Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats. Frontiers in Molecular Neuroscience. 2017;10:36.
Ari C, Kovács Z, Juhasz G, Murdun C, Goldhagen CR, Koutnik AP, Poff AM, Kesl SL, D'Agostino DP. Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats. Frontiers in Molecular Neuroscience. 2016;9:137.
Sanchez-Gonzalez MA, Guzik P, May RW, Koutnik AP, Hughes R, Muniz S, Kebbaj M, Fincham FD. Trait anxiety mimics age-related cardiovascular automin modulation in young adults. Journal of Human Hypertension. 2014;29:274.
Sanchez-Gonzalez MA, May RW, Koutnik AP, Fincham FD. Impact of negative affectivity and trait forgiveness on aortic blood pressure and coronary circulation. Psychophysiology. 2015;52(2):296-303.
Dweck D, Sanchez-Gonzalez MA, Chang AN, Dulce RA, Badger CD, Koutnik AP, Ruiz EL, Griffin B, Liang J, Kabbaj M, Fincham FD, Hare JM, Overton JM, Pinto JR. Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Model of Hypertrophic Cardiomyopathy. The Journal of Biological Chemistry. 2014;289(33):23097-23111.
Koutnik AP, Figueroa, A, Wong A, Ramirez KJ, Ormsbee MJ, Sanchez-Gonzalez MA. Impact of acute whole-body cold exposure with concurrent isometric handgrip exercise on aortic pressure waveform characteristics. Eur J Appl Physiol. 2014;114(9):1779-1787.
Koutnik AP, Sanchez-Gonzalez MA, May RW, Hughes RM, Fincham FD. Impact of psychological distress on cardiovagal reactivation after a speech task. J Hum Hypertens. 2014;28(6):399-401.
May RW, Sanchez-Gonzalez MA, Brown PC, Koutnik AP, Fincham FD. School burnout and cardiovascular functioning in young adult males: a hemodynamic perspective. Stress. 2014;17(1):79-87.
Koutnik AP, Wong A, Kalfron R, Madzima TA, Figueroa A. Acute passive vibration reduces arterial stiffness and aortic wave reflection in stroke survivors. Eur J Appl Physiol. 2014;114(1):105-111.
Sanchez-Gonzalez MA, May RW, Koutnik AP, Kabbaj M, Finchman FD. Sympathetic vasomotor tone is associated with depressive symptoms in young females: a potential link between depression and cardiovascular disease. Am J Hypertens. 2013;26(12):1389-1397.
Sanchez-Gonzalez MA, Koutnik AP, Ramirez K, Wong A, Figueroa A. The effects of short term L-citrulline supplementation on wave reflection responses to cold exposure with concurrent isometric exercise. Am J Hypertens. 2013;26(4):518-526.
Sanchez-Gonzalez MA, May RW, Brown PC, Koutnik AP, Finchman FD. Depressive symptoms contribute to increased wave reflection during cold pressor test in young adult men. Am J Hypertens. 2013;26(6):778-783.